Test Detail
Maternal Screen Integrated Sample 1
Back to Test Directory| Test Description |
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| First trimester sample of a 2-part test to screen for risks of Down Syndrome, Trisomy 18, and Open Neural Tube Defect (NTD). | |||||
| Performed | Avg. Turnaround Time | Method | |||
| Coralville, 8 a.m. - 5 p.m., M-F |
3 - 5 business days | Quantitative Chemiluminescent Immunoassay | |||
| Fee | CPT Code(s) | ||||
| No charge. Included in Maternal Screen Integrated test - Sample 2. | 84163, 84702 | ||||
| Specimen Requirements | |||||
| Specimen Type: | 1 mL Serum, drawn in BOTH first and second trimesters | ||||
| Patient Preparation: | First sample of a 2-part test drawn between 10 weeks 0 days and 13 weeks 6 days gestation. Can be performed without a 1st trimester Nuchal Translucency (NT) measurement, but an NT measurement is preferred. Results require a second sample drawn between 15 weeks 0 days and 20 weeks 6 days gestation. No risks are reported until after Sample 2 is received and tested (Maternal Screen Integrated test). | ||||
| Collection Instructions: | Dating by ultrasound Crown Rump Length (CRL). Serum sample drawn in the first trimester when the CRL is 32-80 mm. Incorrect dating will result in inaccurate risk assessment. Program brochures and patient consent forms are available for order. Red Top Tube: centrifuge and transfer serum to a secondary tube. |
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| Temperature and Stability: | Refrigerated (2-8°C). Specimen must be received within 9 days of collection. | ||||
| Unacceptable Conditions: | Plasma. Samples not collected within the required gestational age range for the test requested. | ||||
| Expected Results: | |||||
| Final interpretive report will be available when the second sample (Maternal Screen Integrated) test results are complete, but a report stating the date range to collect the second sample will be issued. | |||||
| Shipping: | |||||
| Wrap specimen container in absorbent material and place inside a biohazard bag. Transport specimen with cold pack. Ship to the Coralville location. | |||||
| Comments | |||||
| Incorrect information, especially incorrect dating, will result in inaccurate risk assessment. Nuchal Translucency (NT) measurement must be performed by a sonographer certified by FMF or NTQR. The sonographer's name, certification number, and certifying organization must be on file with the laboratory. Call 319/335-4056 the first time a sonographer is submitting an NT measurement with a test request. If NT is unobtainable, order Integrated Screen. The following information is required for test interpretation: Ultrasound date AND Crown Rump Length (CRL) measurement, a NT measurement obtained between 10 weeks 0 days and 13 weeks 6 days is preferred (but not required), patient's date of birth, current weight, patient's race, if patient requires insulin, family history of NTD, and, for IVF pregnancies, the age of the egg donor at time of egg retrieval. This test cannot be performed on multiples. Detection rates: 85% Down Syndrome, 80% Trisomy 18, 85% Neural Tube Defects. False Positive Rate: 2.6% without Nuchal Translucency (NT) measurement, 1.9% with Nuchal Translucency (NT) measurement. Results are available after the second serum sample is processed. If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided. | |||||
| Alternate Names | |||||
| Integrated Screen First Trimester Draw | |||||
