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Maternal Screen NTD Amniotic Fluid

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Test Description
  • Contact: Maternal Screening (319) 335-4247. Interpretation or revised dating information: UIHC OB/GYN Counseling Office (319) 356-8892.
  • Test Request Form: Maternal Screen NTD/Quad
  • SHL OpenELIS Code: 857
Screen for Open Neural Tube Defect (NTD). Positive result reflexes to Maternal Screen ACHE test for confirmation.
Reflex Test(s)
ACHE Test by Immunoelectrophoresis
Performed Avg. Turnaround Time Method
Coralville, 8 a.m. - 5 p.m., M-F
3 - 5 business days Quantitative Chemiluminescent Immunoassay
Fee CPT Code(s)
$45.00 82106
Specimen Requirements
Specimen Type: 2 mL Amniotic Fluid
Patient Preparation: Amniocentesis. Specimen must be collected between 96 and 160 days gestational age for valid results.
Collection Instructions: Use an aliquot tube or tube without preservative to collect amniotic fluid at amniocentesis procedure. Program brochures and patient consent forms are available for order.
Shipping:
Specimens should be stored and shipped under the same conditions. Wrap specimen container in absorbent material and place inside a biohazard bag. Transport specimen with cold pack. Ship to the Coralville location.
Temperature and Stability: Refrigerated (2-8°C). Specimen must be received within 9 days of collection.
Rejection Criteria: Specimens will be rejected if received under these conditions:

Amniotic fluid contaminated with fetal blood cannot be reflexed to ACHE test if Positive. Samples not collected within the required gestational age range for the test requested. Specimens not received in the correct temperature ranges stated under "Temperature and Stability" will be rejected.
Expected Results:
MoM value for AFP (NTD screen); Screen Cutoff established for test; Interpretation/Recommended Action: Negative / No further action or Positive / See ACHE result.
Comments
Incorrect information, especially incorrect dating, will result in inaccurate risk assessment. The following information is required for test interpretation: Patient's date of birth, ultrasound date, AND measurement to date the pregnancy, patient's race, if patient requires insulin, and if there is a known family history of neural tube defects (NTD).
Alternate Names
AFP Amniotic Fluid, Alpha Fetoprotein Amniotic Fluid
The University of Iowa

State Hygienic Laboratory

General inquires
SHL Client Services
319-335-4500 or 1-800-421-IOWA (4692)
ask-shl@uiowa.edu

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