Test Detail
Maternal Screen Quad
Back to Test Directory| Test Description |
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| Screen for risks of Down syndrome, Trisomy 18, and Open Neural Tube Defect (NTD). | |||||
| Performed | Avg. Turnaround Time | Method | |||
| Coralville, 8 a.m. - 5 p.m., M-F |
3 - 5 business days | Quantitative Chemiluminescent Immunoassay | |||
| Fee | CPT Code(s) | ||||
| $125.00 | 82105, 82677, 84702, 86336 | ||||
| Specimen Requirements | |||||
| Specimen Type: | Minimum 1 mL Serum | ||||
| Patient Preparation: | Second trimester screening test for Down Syndrome, Trisomy 18, and Open Neural Tube Defect (spina bifida) drawn between 15 weeks 0 days and 20 weeks 6 days gestation. | ||||
| Collection Instructions: | Program brochures and patient consent forms are available for order. Red Top Tube: centrifuge and transfer serum to a secondary tube. |
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| Shipping: | |||||
| Specimens should be stored and shipped under the same conditions. Wrap specimen container in absorbent material and place inside a biohazard bag. Transport specimen with cold pack. Ship to the Coralville location. | |||||
| Temperature and Stability: | Refrigerated (2-8°C). Specimen must be received within 9 days of collection. | ||||
| Rejection Criteria: |
Specimens will be rejected if received under these conditions: Plasma. Samples not collected within the required gestational age range for the test requested. Specimens not received in the correct temperature ranges stated under "Temperature and Stability" will be rejected. |
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| Expected Results: | |||||
| MoM values for AFP (NTD screen), hCG, Estriol, and Inhibin; Risk Values for Down Syndrome and Trisomy 18; Screen Cutoff established for test; Interpretation/Recommended Action: Negative / No further action or Positive / Level II Ultrasound and/or consideration for amniocentesis. | |||||
| Comments | |||||
| The following information is required for test interpretation: Patient's date of birth, current weight, ultrasound date AND measurement, and/or LMP information to date the pregnancy, number of fetuses, patient's race, if patient requires insulin, and if there is a known family history of neural tube defects (NTD). If IVF pregnancy, the age of the egg donor at time of egg retrieval. Detection rates: 79% Down Syndrome, 80% Trisomy 18, 85% Neural Tube Defects. False positive rate: 3.5%. | |||||
| Alternate Names | |||||
| Quad screening, Quad AFP, AFP 4 Marker Screen, Maternal Quad Screen | |||||
